【原著論文】​​

1. Ono M, Fukunaga Y, Suzuki A, Shirotani S, Mikami A, Nokubo A, Kishihara M, Koike T, Shibahashi E, Minami Y, Yoshida A, Kikuchi N, Hattori H, Shiga T, Daimon M, Ashihara K, Yamaguchi J. Prognostic significance of right ventricular-pulmonary artery coupling assessed by TAPSE/PASP ratio in patients with HFmrEF. Heart Vessels. 2026 Feb;41(2):104-114.

2. Nishizawa T, Shiga T, Amano M, Matsushima H. Challenges in Predicting Intubation in Patients With Severe Coronavirus Disease 2019 (COVID-19) on High-Flow Nasal Cannula: A Focus on Lymphopenia and Conventional Markers. Cureus. 2026 Jan 16;18(1):e101700.

3. Kido K, Shimizu M, Shiga T, Hashiguchi M. Evaluating the Concomitant Use of Diltiazem or Verapamil With Direct Oral Anticoagulants: A Meta-analysis. Ann Pharmacother. 2026 Jan;60(1):36-41. 

4. Elloumi F, Reinhold WC, Varma S, Wang Y, Kinali M, Arakawa Y, Inoue Y, Aladjem MI, Pommier Y, Luna A. CellMiner cross-database (CellMinerCDB) version 2.2 for explorations of patient-derived cancer cell line pharmacogenomics. Nucleic Acids Res. 2026 Jan 6;54(D1):D1345-D1354. 

5. Kido K, Shimizu M, Shiga T, Hashiguchi M. The Concomitant Therapy of Direct Oral Anticoagulants with Amiodarone in Atrial Fibrillation: A Meta-analysis. J Cardiovasc Pharmacol Ther. 2025 Jan-Dec;30:10742484251351148. 

6. Kido K, Hashiguchi M, Guglin M. Patient-Centered Outcomes in Heart Failure Pharmacotherapy: A Meta-Analysis of Randomized Controlled Trials. JACC Adv. 2025 Dec;4(12 Pt 2):102356.

7. Shiga T, Suzuki A, Inoue S, Hashiguchi M. Effect of carperitide on clinical outcomes among patients with acute heart failure: a meta-analysis of randomized and propensity‑matched studies. BMC Cardiovasc Disord. 2025 Nov 27;25(1):896.

8. Shimizu M, Shiga T, Hashiguchi M. A new, patient-friendly, needleless methotrexate administration method using the pyro-drive jet injector in rats. Sci Rep. 2025 Nov 12;15(1):39599. 

9. Hirai T, Kasai H, Shiga T. Population pharmacokinetic analysis of the interaction of digoxin with N-desethylamiodarone in patients with atrial fibrillation and heart failure. Br J Clin Pharmacol. 2025 Oct;91(10):2827-2835.

10. Schultz CW, Saha S, Dhall A, Zhang Y, Desai P, Pongor LS, Scheiblin DA, Magidson V, Shuklah RP, Sebastian R, Vekariya UM, Ahmed S, Sun Y, Redon C, Kumar S, Krishnamurthy M, Dias HB, Aksenova V, Giordano E, Takahashi N, Nirula M, Arora M, Tabe C, Thomas MS, Kumar R, Arakawa Y, Jo U, Skorski T, Teicher BA, Shreshta R, Aladjem MI, Lockett S, Dasso M, Pommier Y, Sharma AK, Thomas A. Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer. Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2503387122.

11. Takatsuka M, Hashiguchi M, Shiga T. H1 antihistamine-induced adverse events and time to onset: A retrospective analysis using the Japanese Adverse Drug Event Report Database. Int J Clin Pharmacol Ther. 2025 Jul;63(7):295-308. 

12. Shiga T, Shiozaki M, Takahashi R, Matsumoto R, Fukui M. Post-Marketing Surveillance of the Safety of Landiolol in Patients With Recurrent Hemodynamically Unstable Ventricular Tachyarrhythmias. Circ J. 2025 May 23;89(6):784-792.

13. Haruki K, Suzuki A, Yoshida A, Ashihara K, Yamaguchi J, Shiga T. Persistently low tricuspid annular plane systolic excursion and its prognosis in Japanese hospitalized patients with heart failure with reduced ejection fraction. Heart Vessels. 2025 May;40(5):391-404.

14. Takei H, Hashiguchi M, Takanashi S, Hanaoka H, Kikuchi J, Yoshimoto K, Shiga T, Shimizu M, Takeuchi T, Kaneko Y. Association between hydroxychloroquine concentrations and its efficacy and safety in Japanese patients with rheumatoid arthritis. Mod Rheumatol. 2025 Mar 25. [Epub ahead of print]

15. Kido K, Shimizu M, Shiga T, Hashiguchi M. Meta-Analysis Comparing Metolazone Versus Intravenous Chlorothiazide in Patients With Acute Decompensated Heart Failure. Ann Pharmacother. 2025 Mar 15. [Epub ahead of print]

16. Ishii S, Arakawa Y, Ishii H, Yokoyama K, Yokoyama H, Saito T, Yano S. A novel stroma-dependent leukemia cell line from a patient with mixed-phenotype acute leukemia with Ph chromosome and PAX5 mutation. Int J Hematol. 2025;121:782-791.

17. Suzuki A, Hashiguchi M, Shiga T. Effect of Carperitide on Clinical Outcomes in Patients with Acute Decompensated Heart Failure: A Subanalysis of the HIJ-HF II Study. Jpn J Clin Pharmacol Ther 2025; 56(2): 63-70.

18. Koike T, Suzuki A, Kikuchi N, Yoshimura A, Haruki K, Yoshida A, Sone M, Nakazawa M, Tsukamoto K, Imamura Y, Hattori H, Kogure T, Yamaguchi J, Shiga T. Prognostic implication of outpatient loop diuretic dose intensification trajectories in patients with chronic heart failure. Int J Cardiol Heart Vasc. 2025; 57:101632.

19. Suzuki A, Shiga T, Sato K, Shoda M, Yamaguchi J. Metabolome analysis in patients with heart failure and implantable cardioverter defibrillators. Heart Vessels. 2025;40(1):86-90.

20. Kikuchi N, Shiga T, Sugawara Y, Suzuki A, Minami Y, Hattori H, Shoda M, Hagiwara N, Yamaguchi J. Clinical outcomes during and after wearable cardioverter defibrillator use in Japanese patients with heart failure: A single-center experience. J Arrhythm. 2024; 40(6):1462-1472.

21. Arakawa Y, Elloumi F, Varma S, Khandagale P, Jo U, Kumar S, Roper N, Reinhold WC, Robey RW, Takebe N, Gottesman MM, Thomas CJ, Boeva V, Berruti A, Abate A, Tamburello M, Sigala S, Hantel C, Weigand I, Wierman ME, Kiseljak-Vassiliades K, Del Rivero J, Pommier Y. A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma Cell Lines, PDX, and Patient Samples. Cancer Res Commun. 2024; 4(9):2384-2398.

22. Koike T, Suzuki A, Kikuchi N, Yoshimura A, Haruki K, Yoshida A, Sone M, Nakazawa M, Tsukamoto K, Imamura Y, Hattori H, Kogure T, Yamaguchi J, Shiga T. Prognostic impact of outpatient loop diuretic reduction patterns in patients with chronic heart failure. Int J Cardiol Heart Vasc. 2024;55:101517.

23. Kido K, Bianco C, Caccamo M, Hashiguchi M, Choo LY, Sokos G. Sacubitril/Valsartan Does Not Change the Use and Dose of Loop Diuretics in Patients With Heart Failure With Reduced Ejection Fraction. J Pharm Pract. 2024;37(3):708-711.

24. Kido K, Kabulski GM, Szymanski TW, Shiga T, Shimizu M, Hashiguchi M. Meta-Analysis Comparing Bivalirudin Versus. Unfractionated Heparin in Adult Patients With Extracorporeal Membrane Oxygenation. J Pharm Pract. 2024;37(2):429-434.

25. 上田 祥貴，吉山 友二，澤田 恵美，志賀 剛, SMAAP-AF Investigators. 直接経口抗凝固薬のアドヒアランス不良な非弁膜症性心房細動患者に対する服薬指導：動機づけ面接からの考察（SMAAP‒AF 研究）.臨床薬理 2024; 55(3):125-132

26. 堀里子，土屋雅美，木崎速人，橋口正行，佐藤倫広，目時弘仁，小原拓，眞野成康.薬学部を有する大学を対象とした副作用報告に関連した薬学教育の実態調査.医薬品情報学.2024;26(3):128-135.

27. Sakai M, Hirai T, Shitara S, Iwamoto T, Shiga T. Comparison of creatinine-based equations for estimating renal function for digoxin dose adjustment in patients with atrial fibrillation and heart failure. Pharmacol Res Perspect 2023; 11: e01050.​​​

28. Shiga T, Kimura T, Fukushima N, Yoshiyama Y, lwade K, Mori F, et al; SMAAP-AF Investigators. Effects of a Pharmacist-Led Educational lnterventional Program on Electronic Monitoring-assessed Adherence to Direct Oral Anticoagulants: A Randomized, Controlled Trial in Patients with Nonvalvular Atrial Fibrillation. Clin Ther 2022; 44: 1494- 1505.

29. Uchikawa M, Hashiguchi M, Shiga T. Drug-Induced QT Prolongation and Torsade de Pointes in Spontaneous Adverse Event Reporting: A Retrospective Analysis Using the Japanese Adverse Drug Event Report Database (2004-2021). Drugs Real World Outcomes 2022; 9: 551-559.

30. Shimizu M, Furudate S, Nagai Y, Shimada K, Ohshima M, Setoguchi K, Hashiguchi M, Yokogawa N. Pharmacokinetics of hydroxychloroquine in Japanese systemic lupus erythematosus patients with renal impairment. Mod Rheumatol 2022: roac113.

31. Nomoto M, Suzuki A, Shiga T, Shoda M, Hagiwara N. Impact of signal-averaged electrocardiography findings on appropriate shocks in prophylactic implantable cardioverter defibrillator patients with nonischemic systolic heart failure. BMC Cardiovasc Disord 2022; 22: 374.

32. Shimizu M, Mizutani E, Shiga T, Hashiguchi M. Comparison of Clinical Equivalence of Infliximab and its Biosimilar Combinations with Methotrexate in the Treatment of Rheumatoid Arthritis. Jpn J Clin Pharmacol Ther 2022; 53:15-24.

33. Kido K, Shimizu M, Shiga T, Hashiguchi M. Meta-analysis comparing inappropriately low dose versus standard dose of direct oral anticoagulants in patients with atrial fibrillation. J Am Pharm Assoc 2022; 62:487-95.

34. Hirai T, Kasai H, Naganuma M, Hagiwara N, Shiga T. Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data. BMC Pharmacol Toxicol 2022; 23:14.

​​​

​​

​

【総説】

1. 志賀　剛.アブレーション時代の薬物治療. 特集ALL about 心房細動. Heart View 2025; 29(8): 814-818.

2. 志賀　剛. リズムコントロール薬（I群抗不整脈、ベプリジル、アミオダロン）の使い方. 心房細動 予防・早期発見・治療の進化. 循環器ジャーナル2024; 72(3): 400-708.

3. 志賀　剛. 不整脈治療. 特集心不全の診療 2024－最新の診断と治療－. 日本臨牀 2024; 82(7): 1082-1087.

4. 志賀　剛. 標準治療薬以外の薬剤の実践的使い方 ジギタリス. 特集心不全治療のFantastic Four どう考え、どう使うか？　治療 2024; 106(10): 1167-1170.

5. 志賀　剛. 抗不整脈薬をもっと知りたい. 心電図判読のスタンダード 基本を極めて臨床で活かす! 臨床検査 2024; 68(10):1311-1315.

6. 志賀　剛. 薬物治療－抗不整脈薬. 不整脈診療学－最近の診断・治療動向－. 日本臨牀 2025; 83（増刊号1）:138-143.

7. 志賀　剛. 不整脈の薬物治療（抗不整脈薬など）．不整脈治療最前線.日本内科雑誌 2025; 114(2): 158-164.

8. Shiga T. Depression and cardiovascular diseases. J Cardiol 2023; 81: 485-490.

9. Shiga T. Benefits and safety of landiolol for rapid rate control in patients with atrial tachyarrhythmias and acute decompensated heart failure. Eur Heart J Suppl 2022; 24: D11-D21.

 

​​​​

【症例報告】

1. Matsui Y, Higuchi S, Yagishita D, Shiga T, Shoda M, Yamaguchi J. Progressive splitting of the QRS complex during 2 decades. Heart Rhythm. 2025 Mar17．[Epub ahead of print]

​

​​

​

【著書】

1. 志賀　剛. 薬剤便覧と臨床解説 17. 利尿薬. 矢崎義雄監修、北原光夫, 上野文昭, 越前宏俊編集. 治療薬マニュアル2026. 東京：医学書院, 2025. p.547-550.

2. 志賀　剛. 薬剤便覧と臨床解説 21. 心不全治療薬. 矢崎義雄監修、北原光夫, 上野文昭, 越前宏俊編集. 治療薬マニュアル2026. 東京：医学書院, 2025. p.641-648.

3. 志賀　剛. 薬剤便覧と臨床解説 22. その他の循環器用薬. 矢崎義雄監修、北原光夫, 上野文昭, 越前宏俊編集. 治療薬マニュアル2026. 東京：医学書院, 2024. p.671-673.

4. 志賀　剛.　循環器疾患 植込み型除細動器. 福井次男、高木　誠、小室一成総編集. 今日の治療指針 2026年版. 東京：医学書院, 2026. p.377-378.

5. 志賀　剛. 添付文書情報と臨床解説 17. 利尿薬. 矢崎義雄監修、北原光夫, 上野文昭, 越前宏俊編集. 治療薬マニュアル2025. 東京：医学書院, 2024. p.555-558.

6. 志賀　剛. 添付文書情報と臨床解説 21. 心不全治療薬. 矢崎義雄監修、北原光夫, 上野文昭, 越前宏俊編集. 治療薬マニュアル2025. 東京：医学書院, 2024. p.651-658.

7. 志賀　剛. 添付文書情報と臨床解説 22. その他の循環器用薬. 矢崎義雄監修、北原光夫, 上野文昭, 越前宏俊編集. 治療薬マニュアル2025. 東京：医学書院, 2024. p.681-683.

8. 志賀　剛.　循環器疾患 心臓神経症. 福井次男、高木　誠、小室一成総編集. 今日の治療指針Vol.67　2025年版. 東京：医学書院, 2025. p.433-434.

9. 志賀　剛. 薬剤師力がぐんぐん伸びる. 専門医がじっくり教える心不全・心房細動. 東京：日経BP, 2024．

​

​

​

​

​

​

​

​